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Synthesis of [21‐ 13 C]‐cholesterol
Author(s) -
Caballero Gerardo M.,
Gros Eduardo G.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340204
Subject(s) - chemistry , nitrile , grignard reaction , iodide , nuclear magnetic resonance spectroscopy , carbon atom , methyl iodide , derivative (finance) , carbon 14 , carbon 13 , medicinal chemistry , stereochemistry , organic chemistry , ring (chemistry) , reagent , financial economics , economics , physics , quantum mechanics
The synthesis of [21‐ 13 C]‐cholesterol ( 5 ) from 3β‐O‐(t‐butyldimethylsilyl)‐17β‐cyano‐androst‐5‐ene ( 1 ) is described. Labelled carbon‐atom was introduced by Grignard reaction of nitrile derivative with [ 13 C]‐methylmagnesium iodide. Location of label was confirmed by 13 C‐NMR spectroscopy.