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Synthesis of [1‐ 14 C]‐2,2‐difluoroethene from [ 14 C]‐formaldehyde
Author(s) -
Ruzicka Jan A.,
Qiu Weiming,
Baker Max T.,
Burton Donald J.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340108
Subject(s) - chemistry , formaldehyde , radiochemistry , nuclear chemistry , organic chemistry
[1‐ 14 C]‐2,2‐Difluoroethene was synthesized from [ 14 C]‐formaldehyde using a modification of the Wadsworth‐Emmons reaction, via formation of the intermediate (EtO) 2 P(O)CF 2 14 CH 2 OSiMe 3 . This highly volatile product was collected in a liquid nitrogen trap at a purity of >97% and specific activity of 0.2 mCi/mmol, with yields of 10 ‐ 15%.