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Synthesis of 11‐[ 3 H]‐arteether, an experimental antimalarial drug
Author(s) -
Pu YuMing,
Ziffer Herman
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580331104
Subject(s) - chemistry , hydrobromide , triphenylphosphine , stereochemistry , ethanol , organic chemistry , catalysis
The triphenylphosphine hydrobromide‐catalyzed addition of a proton from ethanol to anhydrodihydroartemisinin ( 5 ) has been employed for the synthesis of 2 and 4 Use of 1.5 equivalents of EtO 2 H or EtO 3 H yielded 11‐[ 3 H]‐β‐arteether as the major product.