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The preparation of tritium labelled biocompatible polymers
Author(s) -
Russell Jeremy C.,
Jones John R.,
Vick Terrence A.,
Stratford Peter W.
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580331010
Subject(s) - chemistry , tritium illumination , tritium , polymer , lanthanide , reagent , homogeneous , catalysis , radiochemistry , nuclear chemistry , organic chemistry , polymer chemistry , ion , physics , nuclear physics , thermodynamics
The preparation of tritiated phosphoryl choline containing linear polymers by the reduction of an acetylenically unsaturated polymer with tritium gas is described. Homogeneous catalysis was used and the product was analysed by 1 H and 3 H‐nmr spectroscopy. The use of lanthanide shift reagents showed that 98% of the isotope was located in the 7 and 8 positions of the hydrophobic chains.