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Synthesis of [ 3 H]cyfluthrin
Author(s) -
Pleiß Ulrich,
Römer Johannes,
Thomas Rudolf
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580331009
Subject(s) - chemistry , cyfluthrin , biotransformation , tritium , tritium illumination , labelling , radiochemistry , catalysis , nuclear magnetic resonance spectroscopy , nuclear chemistry , stereochemistry , organic chemistry , biochemistry , enzyme , pesticide , physics , deltamethrin , nuclear physics , agronomy , biology
For the elucidation of the distribution and biotransformation of Cyfluthrin in tse‐tse flies the tritium‐labelled compound was needed. A brominated precursor was dehalogenated with tritium gas using a special noble metal catalyst to give the desired [ 3 H]Cyfluthrin. The labelling position was confirmed by 3 H‐NMR spectroscopy. After synthesis and purification, the [ 3 H]Cyfluthrin obtained showed a specific activity of 23.7 Ci/ mmol (877 GBq/mmol).