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Synthesis of [20,21‐ 13 C 2 ]‐pregnenolone
Author(s) -
Caballero Gerardo M.,
Gros Eduardo G.
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580331004
Subject(s) - chemistry , nitrile , pregnenolone , grignard reaction , derivative (finance) , iodide , condensation , nuclear magnetic resonance spectroscopy , organic chemistry , steroid , biochemistry , physics , reagent , hormone , financial economics , economics , thermodynamics
The synthesis of [20,21‐ 13 C 2 ]‐pregnenolone (7) from androst‐5‐en‐3β‐ol‐17‐one ( 1 ) is described. Labelled carbons were introduced by two procedures, namely, condensation of 1 with K 13 CN and Grignard reaction of nitrile derivative 5 with [ 13 C]‐methylmagnesium iodide. Location of labels was confirmed by 13 C‐NMR spectroscopy.