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A synthetic approach to carbon‐14 labeled anti‐bacterial napthyridine and quinolone carboxylic acids
Author(s) -
Ekhato I. Victor,
Huang Che C.
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330911
Subject(s) - chemistry , carboxylation , carboxylic acid , quinolone , halogen , organic chemistry , carbon fibers , combinatorial chemistry , antibiotics , biochemistry , alkyl , materials science , composite material , composite number , catalysis
Labeled versions of (S)‐clinafloxacin ( 1 ) and two naphthyridine carboxylic acid anti‐bacterial compounds 2 and 3 which are currently in development were synthesized. Preparations started from hitherto unknown bromo compounds 22 and 10 , from which the corresponding 14 C‐labeled aromatic carboxylic acids 23 and 12 were generated by metal‐halogen exchange followed by carboxylation reaction. Details of these preparations are given.