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The Synthesis of [ methylenedioxy ‐ 14 C]paroxetine BRL 29060A
Author(s) -
Lawrie K W M,
Rustidge D C
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330814
Subject(s) - methylenedioxy , chemistry , paroxetine , stereochemistry , yield (engineering) , organic chemistry , biochemistry , serotonin , alkyl , receptor , materials science , halogen , metallurgy
Paroxetine ( 1 ), BRL 29060A, a potent antidepressant, has been prepared radiolabelled with carbon‐14 in the methylenedioxy group in 5 steps and 20.9% overall yield from [ 14 C]dibromomethane. Two altenative preparations of 3,4‐[ methylenedioxy ‐ 14 C]phenol ( 2 ) are also described.