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The synthesis and resolution of tritiated 4‐amino‐3‐phenylbutanoic acid ([ 3 H] R ‐ and [ 3 H] S ‐β‐phenylgaba)
Author(s) -
Duke Rujee K.,
Allan Robin D.,
Drew Colleen A.,
Johnston Graham A. R.,
Mewett Kenneth N.,
Long Mervyn A.,
Than Chit
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330813
Subject(s) - chemistry , diastereomer , tritium , tritium illumination , amino acid , catalysis , catalytic hydrogenation , resolution (logic) , palladium , charcoal , stereochemistry , organic chemistry , biochemistry , physics , artificial intelligence , computer science , nuclear physics
A synthesis of [ 3 H] R ‐ and [ 3 H] S ‐4‐amino‐3‐phenylbutanoic acid ([ 3 H] R ‐ and [ 3 H] S ‐β‐phenylGABA) from the unsaturated intermediate by catalytic hydrogenation using tritium gas in the presence of palladium on charcoal is reported. The [ 3 H] R ‐ and [ 3 H] S ‐diastereoisomers of pantolactone ester of β‐phenylGABA were separated by HPLC.