Premium
14 C‐labelling of NNC 756, a new dopamine D 1 antagonist
Author(s) -
Foged Christian,
Hansen Louis B.,
Halldin Christer
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330811
Subject(s) - chemistry , labelling , yield (engineering) , methyl iodide , iodide , radiochemistry , antagonist , d 1 , specific activity , benzazepine , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , enzyme , receptor , materials science , metallurgy
A 14 C labelled form of (+)‐8‐chloro‐5‐(2,3‐dihydrobenzofuran‐7‐yl)‐7‐hydroxy‐3‐methyl‐2,3,4,5‐tetrahydro‐1H‐3‐benzazepine (NNC 756) ( 8 ) was synthesized in 7 steps, including resolvation of the active (+)‐form, starting from [ 14 C]methyl iodide and 7‐benzofurancarbaldehyde. The overall radiochemical yield was 11%. The radiochemical purity of [4‐ 14 C]NNC 756 was higher than 98% with a specific radioactivity of 24 mCi/mmol.