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Synthesis of [ 3 H]‐labelled glucobrassicin, a potential radiotracer for metabolic studies of indole glucosinolates
Author(s) -
Chevolleau S.,
Joseph B.,
Rollin P.,
Tulliez J.
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330714
Subject(s) - glucosinolate , chemistry , indole test , cruciferous vegetables , myrosinase , stereochemistry , organic chemistry , brassica , botany , cancer , biology , medicine
Glucobrassicin, an indole glucosinolate widespread in cruciferous plants, appears to be involved in anticarcinogenic activity via its breakdown products. In order to study the “in vivo” metabolism of glucobrassicin, we have synthesized the 5‐[ 3 H]‐indol‐3‐ylmethyl glucosinolate ( 3 H‐labelled glucobrassicin) starting from artificial peracetylated 5‐bromoindol‐3‐ylmethyl glucosinolate. The labelled compounds were characterized by radio‐HPLC and FAB mass spectrometry.