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A rapid method for the synthesis of 5‐iodo‐2′‐ deoxyuridine (IUDR) and optimisation of the parameters
Author(s) -
Trivedi Mahendra A.
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330707
Subject(s) - chemistry , halogenation , deoxyuridine , combinatorial chemistry , organic chemistry , chromatography , biochemistry , dna
A modified method for the synthesis of radioiodinated 5‐iodo‐2′‐deoxyuridine based on electrophillic iodination using concentrated HNO 3 as an oxidising agent is described. It is easy, quick, reproducible and yields consistently high (>95%) radiolabelled IUDR. This method avoids refluxing at high temperatures, thereby saving preparation time and improving safety.