Premium
Synthesis of [ 18 F]fluoroethoxy‐benzovesamicol, a radiotracer for cholinergic neurons
Author(s) -
Mulholland G. Keith,
Jung YongWoon,
Wieland Donald M.,
Kilbourn Michael R.,
Kuhl David E.
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330704
Subject(s) - chemistry , cholinergic , yield (engineering) , positron emission tomography , cholinergic neuron , nucleophile , pet imaging , radiochemistry , neuroscience , physics , organic chemistry , psychology , thermodynamics , catalysis
Full experimental details are given for the preparation of [ 18 F]fluoroethoxy‐benzovesamicol, (−)‐( 2R, 3R )‐ trans ‐2‐hydroxy‐3‐(4‐phenylpiperidino)‐5‐(2‐[ 18 F]fluoroethoxy)‐1,2,3,4‐tetralin, a new fluorine‐18 labeled cholinergic neuron mapping agent for use in positron emission tomography (PET). This radiotracer was made by nucleophilic radiofluorination of tosyloxyethoxy‐benzovesamicol, followed by reverse phase HPLC purification, in decay corrected radiochemical yield exceeding 60%.