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Convenient preparation of Boc‐L‐[4‐ 15 N]asparagine and ‐[5‐ 15 N]glutamine for application in peptide synthesis
Author(s) -
Lankiewicz Leszek,
Grehn Leif,
Ragnarsson Ulf
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330613
Subject(s) - chemistry , hydrogenolysis , asparagine , glutamine , catalysis , peptide , ammonia , peptide synthesis , organic chemistry , combinatorial chemistry , amino acid , biochemistry , enzyme
The title compounds have been prepared by a simple and economical procedure from the corresponding Bocprotected α‐benzyl esters and [ 15 N]ammonia with N,N′‐carbonyldiimidazole as coupling agent. Catalytic hydrogenolysis furnished both labelled products in high overall yields suitable for synthetic work.