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The preparation of tritiated E ‐ and Z ‐4‐aminobut‐2‐enoic acids, conformationally restricted analogues of the inhibitory neurotransmitter 4‐aminobutanoic acid (GABA)
Author(s) -
Duke Rujee K.,
Allan Robin D.,
Drew Colleen A.,
Johnston Graham A. R.,
Mewett Kenneth N.,
Long Mervyn A.,
Than Chit
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330610
Subject(s) - chemistry , stereochemistry , neurotransmitter , inhibitory postsynaptic potential , biochemistry , receptor , neuroscience , biology
A synthesis of [ 3 H] E ‐ and [ 3 H] Z ‐4‐aminobut‐2‐enoic acids from methyl 4‐ N ‐phthalimidobut‐2‐ynoate by catalytic hydrogenation using tritium gas in the presence of a homogeneous catalyst, tris (triphenylphosphine)rhodium(I) chloride, is reported. HPLC separation of the E ‐ and Z ‐isomers, and the saturated analogue, 4‐aminobutanoic acid (GABA), is also described.