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The synthesis of 5′‐[ 14 C 1 ] and 3a, 4‐[ 13 C 2 ] labelled panadiplon (U‐78875; 3‐(5′‐cyclopropyl‐1,2,4‐oxadiazol‐3‐yl)‐5‐(1‐methylethyl)‐imidazo‐[1,5a]‐quinoxalin‐4(5H)‐one).
Author(s) -
Ackland M. J.,
Howard M. R.,
Dring L. G.
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330609
Subject(s) - chemistry , oxalic acid , cyclopropane , stereochemistry , labelling , medicinal chemistry , organic chemistry , ring (chemistry) , biochemistry
5′‐[ 14 C 1 ]Panadiplon was prepared in 3 steps starting from [ 14 C 1 ]cyclopropane carboxylic acid and 3‐(5′‐cyano‐1,2,4‐oxadiazol‐3‐yl)‐5‐(1‐methylethyl)‐imidazo‐[1,5a]‐quinoxalin‐4(5H)‐one. 3a, 4‐[ 13 C 2 ]Panadiplon was prepared in two steps from 13 C 2 ‐oxalic acid and N‐1‐(1‐methylethyl)‐o‐phenylenediamine. The position of labelling was confirmed by the appearance of two coupled resonances (J C‐C =80.59 Hz) at 121.95 and 154.39 ppm in the assigned 13 C‐NMR spectrum.