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True tracer radiolabeling of gadolinium complex of 10‐(2‐hydroxypropyl)‐1,4,7,10‐tetraazacyclododecane‐1,4,7 triacetic acid (HP‐DO3A)
Author(s) -
Kumar Krishan,
Sukumaran K.,
Chang C. Allen,
Tweedle M. F.,
Eckelman W. C.
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330605
Subject(s) - chemistry , tracer , gadolinium , radiochemistry , ligand (biochemistry) , dodecane , high performance liquid chromatography , dota , chromatography , chelation , nuclear chemistry , organic chemistry , biochemistry , physics , receptor , nuclear physics
True tracer radiolabeling, purification, and analysis of a gadolinium complex of HP‐DO3A (10‐(2‐hydroxy‐propyl)‐1,4,7,10‐tetraazacyclo dodecane‐1,4,7‐triacetic acid) was achieved by the reaction of carrier‐added 153 GdCl 3 and excess free ligand. Two analytical methods (ITLC and HPLC) were developed to determine the purity of radiolabeled samples.