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Indolealkylamine metabolism: Synthesis of deuterated indolealkylamines as metabolic probes
Author(s) -
Morris Philip E.,
Chiao Cheng
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330603
Subject(s) - chemistry , deuterium , amide , kinetic isotope effect , metabolism , lithium (medication) , isotopic labeling , in vivo , chemical synthesis , stereochemistry , biochemistry , organic chemistry , in vitro , medicine , physics , microbiology and biotechnology , quantum mechanics , biology , endocrinology
The synthesis of the deuterium labeled, endogenously occurring, indolealkylamine hallucinogens N,N ‐dimethyltryptamine and 5‐methoxy‐ N,N ‐dimethyltryptamine via reduction of amide intermediates with lithium aluminum deuteride is described. The compounds were characterized with 1 H, 2 H and 13 C NMR. These compounds were synthesized for use as probes for investigating the metabolism of these compounds by MAO via the in vivo kinetic isotope effect.