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Technetium‐99m‐dimethylglyoxime ( 99m Tc‐DMG) as renal imaging agent
Author(s) -
Adonaylo Vivia.,
Stahl Adriana,
Cañellas Carlos O.,
Pomilio Alicia B.,
Vitale Arturo A.
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330602
Subject(s) - chemistry , dimethylglyoxime , technetium 99m , technetium , biodistribution , excretion , renal function , renal physiology , radiochemistry , kidney , opossum , scintigraphy , medicine , nuclear chemistry , biochemistry , in vitro , inorganic chemistry , anatomy , cobalt
Dimethylglyoxime (DMG) labelled with 99m Tc is here presented as a renal imaging agent. The behaviour of this complex was analysed at different pH by means of UV spectral data and using DMG‐calcium chloride as a reference complex. Biokinetic data were evaluated in two biological models, Sprague‐Dawley rats and Didelphis albiventris argentine opossum. Biodistribution in rats demonstrated fast and specific renal excretion. Time‐activity vabues over both kidneys could be quantified for this complex. Renographic studies led to mean time‐to maximum values on twelve assays of 2.0 ± 0.1 min and a mean relative function of 53.0 ± 2.3 and 47.0 ± 3.2 for right and left kidneys, respectively. 99m Tc‐DMG showed specificity for the renal excretion pathway and therefore Seems to be a very useful radiopharmaceutical for renal function studies.