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Introduction of tritium into organic compounds by isotope exchange reactions
Author(s) -
Myasoedov N. F.
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330505
Subject(s) - chemistry , tritium , hydrogen isotope , yield (engineering) , catalysis , kinetic isotope effect , hydrogen , isotope , solvent , radiochemistry , organic solvent , inorganic chemistry , organic chemistry , deuterium , chemical engineering , physics , materials science , quantum mechanics , nuclear physics , engineering , metallurgy
Various isotope exchange reactions for the introduction of tritium into a range of organic compounds have been investigated. The influence of the catalyst, solvent and reaction conditions on the yield and specific activities of a number of steroids, phytohormones and sugars are reported. Heterogeneous hydrogen isotope exchange with gaseous tritium has also been used to label a number of nonpolar compounds. Similarly the potential of solid state hydrogen isotope exchange has been explored. The reaction mechanism is discussed as well as the influence of the reaction conditions on the specific activity and the label distribution.