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Preparation and biodistribution of a technetium cationic complex ‐ [Tc III (sacac) 2 en(PPh 3 ) 2 ] +
Author(s) -
Vavouraki H.,
Papadopoulos M.,
Mastrostamatis S.,
Varvarigou A. D.,
Psilla M.,
Chiotellis E.
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330402
Subject(s) - chemistry , biodistribution , technetium , cationic polymerization , hexafluorophosphate , acetylacetone , triphenylphosphine , radiochemistry , tricine , nuclear chemistry , ligand (biochemistry) , medicinal chemistry , inorganic chemistry , organic chemistry , biochemistry , ionic liquid , receptor , in vitro , catalysis
The new, “mixed‐ligand”, Tc III ‐N, N′‐ethylene‐bis‐(acetylacetone‐thioiminato)‐bis‐(triphenylphosphine)–hexafluorophosphate complex, corresponding oxo‐technetium (V) precursor with triphenylphoshine, in methanol. It was characterized by elemental analysis, IR, UV‐Vis and 1 H NMR spectroscopy and HPLC. Biodistribution studies showed a considerable heart uptake, but rather slow blood clearance and hepatic elimination.