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Preparation of 9‐ cis ‐retinoic acid [11,12‐ 3 H(N)] by photochemical isomerization
Author(s) -
Dawson Marcia I.,
Hobbs Peter D.,
Cameron James F.,
Rhee Sung W.
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330310
Subject(s) - chemistry , isomerization , photochemistry , retinoic acid , photoisomerization , medicinal chemistry , organic chemistry , biochemistry , catalysis , gene
All‐ trans ‐Retinoic acid [11,12‐ 3 H(N)] was photochemically isomerized using a fluorescent source to afford a mixture of isomeric retinoic acids, from which 9‐ cis ‐retinoic acid[11,12‐ 3 H(N)] was isolated by reversed‐phase HPLC. The identity of 9‐ cis ‐retinoic acid [11, 12‐ 3 H 2 ] was confirmed by coinjection with the unlabeled acid.