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Synthesis of a radiotracer for studying dopamine uptake sites in vivo using PET: 2β‐carbomethoxy‐3β‐(4‐fluorophenyl)‐[N‐ 11 C‐methyl]tropane ([ 11 C]CFT or [ 11 C]WIN‐35,428)
Author(s) -
Dannals Robert F.,
Neumeyer John L.,
Milius Richard A.,
Ravert Hayden T.,
Wilson Alan A.,
Wagner Henry N.
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330209
Subject(s) - chemistry , tropane , derivatization , high performance liquid chromatography , in vivo , chemical synthesis , methylation , bicyclic molecule , stereochemistry , medicinal chemistry , in vitro , chromatography , biochemistry , microbiology and biotechnology , gene , biology
2β‐Carbomethoxy‐3β‐(4‐fluorophenyl)‐[N‐ 11 C‐methyl]tropane, a potent inhibitor of dopamine transport, was prepared by N‐methylation of the appropriate nor‐methyl precursor in DMF with [ 11 C]iodomethane. After derivatization of unreacted precursor with a long chain acyl halide, the radiotracer was purified using reversed phase semipreparative HPLC. The average specific activity was 3065 mCi/μmole (calculated at the end‐of‐synthesis; EOS). The average time of synthesis including formulation was approximately 21 minutes.