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Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol
Author(s) -
Ackland M. J.,
Howard M. R.,
Jacobsen E. J.,
Secreast S. L.,
Dring L. G.
Publication year - 1993
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580330107
Subject(s) - chemistry , benzopyran , pyrimidine , barbituric acid , stereochemistry , bicyclic molecule , medicinal chemistry , organic chemistry
Abstract This paper describes the synthesis and characterisation of 2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]‐[ 14 C]‐ methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol and 2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐[ 13 C 2 ]‐pyrimidinyl)‐1‐ piperazinyl]‐[ 13 C]‐methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐ benzopyran‐6‐ol. Intermediates in the synthesis included R‐(+)‐[ 13 C]‐Trolox®(R‐(+)‐6‐hydroxy‐2,5,7,8‐tetramethylchroman‐[2‐ 13 C]‐carboxylic acid), [2,5‐ 13 C 2 ]‐barbituric acid, 2,4,6‐trichloro‐[2,5‐ 13 C 2 ]‐pyrimidine, 2,6‐di‐pyrrolidinyl‐4‐chloro‐[2,5‐ 13 C 2 ]‐pyrimidine and 4‐(1‐piperazinyl)‐2,6‐di‐1‐pyrrolidinyl‐[2,5‐ 13 C 2 ]‐ pyrimidine.