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Synthesis of Hexadecylphospho[methyl‐ 14 C]‐choline
Author(s) -
Geilen C. C.,
Samson A.,
Wieder Th.,
Wild H.,
Reutter W.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580311216
Subject(s) - chemistry , choline , yield (engineering) , column chromatography , salt (chemistry) , ammonium , silica gel , total synthesis , chemical synthesis , specific activity , chromatography , radiochemistry , nuclear chemistry , stereochemistry , organic chemistry , biochemistry , in vitro , enzyme , materials science , metallurgy
Hexadecylphospho[methyl‐ 14 C]‐choline was synthesized in two steps from the tetra‐n‐butyl‐ammonium salt of phosphoryl[methyl‐ 14 C]‐choline and 1‐bromohexadecane, and purified by column chromatography on silica gel. The total yield of the radioactive synthesis was 35%, whereas the total yield of the non‐radioactive synthesis was 40%. Hexadecylphospho[methyl‐ 14 C]‐choline may serve as a useful tool for pharmacokinetic and biochemical studies of this new antitumor drug.