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The synthesis of [ 14 C] labelled Eutypine
Author(s) -
Defrancq Eric,
Tabacchi Raffaele
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580311214
Subject(s) - chemistry , benzaldehyde , wittig reaction , vineyard , methyl iodide , iodide , stereochemistry , radiochemistry , organic chemistry , catalysis , horticulture , biology
The synthesis of radiolabelled 4‐hydroxy‐3‐(3‐methyl‐3‐buten‐1‐ynyl) benzaldehyde (eutypine 1 ), a phytotoxic compound isolated from the culture media of the fungus Eutypa lata , responsible for vineyard die‐back, is described. The radioisotope 14 C was introduced via a Wittig reaction using [ 14 C] methyl‐iodide as precursor.