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Preparation of mono‐ 15 N‐cyanogen and mono‐ 13 C‐cyanogen
Author(s) -
Wilmes Rolf,
Winnewisser Manfred
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580311211
Subject(s) - cyanogen , chemistry , cyanogen bromide , phosphorus pentoxide , dehydration , pentoxide , radiochemistry , organic chemistry , vanadium , biochemistry , peptide sequence , gene
The preparation of the unsymmetrically isotope‐labelled title compounds was achieved in pure form for the first time. While mono‐ 15 N‐cyanogen is available in a two‐step‐synthesis, the preparation of mono‐ 13 C‐cyanogen requires five steps, the last step in both cases being the dehydration of mono‐ 15 N‐e.g. mono‐ 13 C‐oxamide with phosphorus pentoxide.