Premium
Synthesis of N‐[ 11 C]‐methyl‐L‐DOPA
Author(s) -
Horti Andrew,
Ravert Hayden T.,
Dannals Robert F.,
Wagner Henry N.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580311210
Subject(s) - chemistry , methylation , sodium hydride , tetrahydrofuran , catalysis , sodium , medicinal chemistry , organic chemistry , biochemistry , dna , solvent
The radiochemical synthesis of N‐[ 11 C‐methyl]‐L‐DOPA was accomplished by N‐methylation of the methyl and ethyl esters of L‐N‐tert‐butyl‐oxycarbonyl‐[β‐(3,4‐dimethoxyphenyl)] alaninate with [ 11 C]iodomethane using sodium hydride in tetrahydrofuran and deprotection of the N‐methyl intermediate with hydriodic acid. A catalytic influence of Kryptofix on the methylation reaction was observed. Using the ethyl ester precursor, the average specific activity at the end‐of‐synthesis was 972 mCi/μmole. The synthesis was completed in an average of 45 minutes following the end‐of‐bombardment.