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Marquage par 14 C et 3 H du 4,4‐dimethyl‐1‐(methylendioxy‐3,4 phenyl)‐1‐pentene‐3‐ ol ou stiripentol
Author(s) -
Madelmont J. C.,
Dupuy J. M.,
Rapp M.,
Labarre P.,
Maurizis J. C.,
Lepage F.,
Veyre A.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580311116
Subject(s) - chemistry , pentene , stereochemistry , medicinal chemistry , organic chemistry , catalysis
4,4‐dimethyl‐1‐(3‐4‐methylenedioxyphenyl)‐1‐pentene‐3‐ol or stiripentol was labelled by 14 C and 3 H. 14 C labelling was performed on the carbone 1 of the pentene group via a four steps procedure after the carbonatation. The radiochemical yield calculated from the precursor (Ba 14 CO 3 ) is 28%. 3 H labelling was performed on the position 3 of the pentene chain by reduction of the corresponding cetone via NaBT 4 . The radiochemical yield calculated from the precursor (NaBT 4 ) is 40%.