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Synthesis of an iodine‐125‐labeled retinoid
Author(s) -
Dawson Marcia I.,
Hobbs Peter D.,
Rhee Sung W.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580311105
Subject(s) - chemistry , iodine , radiochemistry , retinoid , combinatorial chemistry , organic chemistry , biochemistry , retinoic acid , gene
The carrier‐free synthesis of 4‐(5′,6′,7′,8′‐tetrahydro‐4′‐[ 125 I]iodo‐5′,5′,8′,8′‐tetramethyl‐2′‐anthracenyl)benzoic acid (4′‐[ 125 I]TTAB) is described. Site specific radioiodination was accomplished by electrophilic destannylation of the tri( n ‐butyl)tin analog of the retinoid with Na 125 I and chloramine‐T. 4′‐[ 125 I]TTAB (33 μCi, 1.65% radiochemical yield based on Na 125 I consumed) was purified by reversedphase HPLC.