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Synthesis of 2‐chloroethyl ( 13 C)‐methyl sulfide
Author(s) -
Taber Douglass F.,
Meagley Robert P.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580311102
Subject(s) - chemistry , thionyl chloride , methyl iodide , sulfide , iodide , chloride , isotope , dimethyl sulfide , radiochemistry , organic chemistry , medicinal chemistry , sulfur , physics , quantum mechanics
Incorporation of a stable isotope‐labelled methylthio group into the mustard 2‐chloroethyl methyl sulfide 2 was complicated by concomitant reaction with iodide ion, a necessary byproduct from the precursor stable isotope‐labelled iodomethane. A two step procedure was therefore employed, initial displacement with mercaptoethanol 4 being followed by chlorination with thionyl chloride.