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Solid‐phase catalytic isotope exchange of alkylxanthines with gaseous tritium
Author(s) -
Kaminski Ju. L.,
Akulov G. P.,
Patoki. A.,
Rosenberg S. G.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580311004
Subject(s) - chemistry , tritium , catalysis , alkyl , radiochemistry , tritium illumination , isotope , phase (matter) , nuclear chemistry , organic chemistry , nuclear physics , physics
The results of the synthesis of 11 different tritiated alkylxanthines by solid‐phase catalytic isotope exchange are described. 3 H‐NMR analysis of the labelled compounds shows that in contrast to liquid‐phase isotope exchange the tritium label is incorporated not only in the C‐8 (H) position, but also in the alkyl groups. The fraction of radioactivity in an alkyl group depends on the nature and position of this group.