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Synthesis of unlabelled and tritium labelled 4‐isothiocyanato‐1‐(1‐phenylcyclohexyl)piperidine (fourphit), tools for the study of the dopamine reuptake complex.
Author(s) -
Linders Joannes T. M.,
de Costa Brian R.,
Grayson Neile A.,
Rice Kenner C.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580310906
Subject(s) - chemistry , piperidine , dopamine , reuptake , tritium , pharmacology , stereochemistry , serotonin , psychology , neuroscience , biochemistry , medicine , physics , receptor , nuclear physics
The synthesis of high specific activity tritium labelled 4‐isothiocyanato‐1‐(1‐phenylcyclohexyl)piperidine ([ 3 H]fourphit), a probe for the autoradiographic study of the dopamine reuptake complex, is described. An improved, facile synthesis of unlabelled fourphit in high overall yield is also presented. Detailed study of the interaction of unlabelled and tritium labelled fourphit with the dopamine reuptake complex may lead to a better understanding of the actions of cocaine.