Premium
Synthesis of tritium‐labelled imipramine and desipramine with high specific activities
Author(s) -
Yakovleva L. A.,
Kaminski Ju. L.,
Sosnova L. P.,
Kudelin B. K.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580310904
Subject(s) - desipramine , chemistry , tritium , imipramine , catalysis , radiochemistry , nuclear chemistry , organic chemistry , medicine , physics , alternative medicine , pathology , nuclear physics , hippocampus , antidepressant
[G‐ 3 H]imipramine and [G‐ 3 H]desipramine with specific activities 110–160 and 80–100 kCi/mol, respectively were synthesized by high temperature solid‐phase catalytic isotope exchange with gaseous tritium.