Premium
A simple procedure for producing oxygen‐labelled inorganic phosphate from isotopically labelled water that optimizes yield based on the isotope
Author(s) -
Ray William J.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580310810
Subject(s) - chemistry , diethylamine , yield (engineering) , phosphorus pentachloride , phosphate , stoichiometry , phosphorus , oxygen , chlorine , isotopes of oxygen , inorganic chemistry , radiochemistry , organic chemistry , nuclear chemistry , materials science , metallurgy
Phosphorus pentachloride can be treated with stoichiometric amounts of oxygen‐labelled water to produce 80–90 percent yields of labelled inorganic phosphate when the reaction is conducted in dioxane. Any phosphorus‐chlorine bonds remaining at the end of the reaction are eliminated by reaction with diethylamine prior to adding water.