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Synthesis of D‐(‐)‐[1,7‐ 13 C 2 ]shikimic acid
Author(s) -
Cho Hyeongjin,
Heide Lutz,
Floss Heinz G.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580310804
Subject(s) - shikimic acid , chemistry , synthon , phosphonate , yield (engineering) , shikimate pathway , chemical synthesis , carbon 13 , carbon 14 , organic chemistry , carbon fibers , stereochemistry , nuclear chemistry , biosynthesis , biochemistry , in vitro , materials science , physics , composite material , quantum mechanics , composite number , metallurgy , enzyme
The chemical synthesis of 99% enriched D(‐)‐[1,7‐ 13 C 2 ]shikimic acid from [1,2‐ 13 C 2 ]acetate in 25% overall yield is described. A two‐carbon phosphonate synthon was prepared from [1,2‐ 13 C 2 ]acetate and used in the shikimate synthesis of Fleet and coworkers.