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Synthesis of iodobuprenorphine for use in radioimmunoassay
Author(s) -
Debrabandere L.,
van Boven M.,
Daenens P.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580310803
Subject(s) - chemistry , radioimmunoassay , chloramine t , iodide , sodium iodide , halogenation , chromatography , mass spectrometry , combinatorial chemistry , organic chemistry , biochemistry
The synthesis of [ 125 I]iodobuprenorphine is described. This compound has been used as a tracer molecule in the development of a new radioimmunoassay for buprenorphine. The parameters that effect the direct iodination of buprenorphine using sodium [ 127 I]iodide, in the presence of either chloramine‐T or Iodo‐Beads ® , were previously studied. The structure of iodobuprenorphine was confirmed by mass spectrometry.