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The synthesis of [ 14 C]pantoprazole ‐ SK&F 96022Z. An H + /K + ATPase inhibitor
Author(s) -
Crowe A. M,
Johnston C. E. A,
Lawrie K. W. M,
Saunders D
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580310511
Subject(s) - chemistry , pantoprazole , atpase , benzimidazole , stereochemistry , enzyme , biochemistry , pharmacology , organic chemistry , omeprazole , medicine
Pantoprazole 1 , SK & F 96022Z, an H + /K + ATPase inhibitor has been prepared, radiolabelled with carbon‐14, in two positions, for drug metabolism studies. [ Benzimidazole ‐2‐ 14 C]Pantoprazole in 4 steps from potassium ethyl [ 14 C]xanthate, and [ pyridylmethyl ‐ 14 C]pantoprazole from cuprous [ 14 C]cyanide in 8 steps. The overall radiochemical yields of these syntheses were 37.9% and 5.2% respectively.