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Synthesis of (2‐methyl‐4‐nitro‐1‐[ 15 N 1 ]imidazolyl)acetic acid
Author(s) -
Suwinski Jerzy,
Szczepankiewicz Wojciech
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580310212
Subject(s) - chemistry , acetic acid , yield (engineering) , nitro , glycine , medicinal chemistry , nitrogen , nitroimidazole , stereochemistry , organic chemistry , amino acid , alkyl , biochemistry , materials science , metallurgy
1,4‐Dinitro‐2‐methylimidazole reacts under mild conditions with glycine to yield (2‐methyl‐4‐nitro‐1‐imidazolyl)acetic acid. The use of [ 15 N]glycine gives a product having a labelled nitrogen in 1 position of 4‐nitroimidazole.