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Further investigation on the radiosynthesis of α‐[ 11 C]methyl‐tryptophan
Author(s) -
Suehiro Makiko,
Ravert Hayden T.,
Wilson Alan A.,
Scheffel Ursula,
Dannals Robert F.,
Wagner Henry N.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580310211
Subject(s) - chemistry , radiosynthesis , tryptophan , organic chemistry , deprotonation , amino acid , biochemistry , microbiology and biotechnology , in vivo , biology , ion
Improved procedures for the radiosynthesis of α‐[ 11 C]methyltryptophan and α‐[ 11 C]methyl‐tryptophan methyl ester were studied. Following α‐deprotonation of tryptophan methyl ester benzaldimine with LDA, 60 – 80% of no carrier added [ 11 C]iodomethane was incorporated in 5 minutes at 27 – 30°C. After HPLC purification, radiochemically pure α‐[ 11 C]methyl‐tryptophan or its methyl ester was produced with minimum chemical contamination from tryptophan. The [ 11 C]methyl‐tryptophan synthesized, however, was found to be a racemate.