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Preparation and evaluation of cationic 99 Tc/ 99m Tc dimethoxy‐ and diethoxy‐hexanedione dioxime complexes
Author(s) -
Su Z. F.,
Linse K. H.,
Steinmetz H. J.,
Schwochau K.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580310108
Subject(s) - chemistry , lipophilicity , cationic polymerization , partition coefficient , pertechnetate , nuclear chemistry , octanol , medicinal chemistry , high performance liquid chromatography , mass spectrometry , boron , radiochemistry , inorganic chemistry , stereochemistry , technetium , chromatography , organic chemistry
The new ligands 1,6‐dimethoxy‐3,4‐hexanedione dioxime (DMHD) and 1,6‐diethoxy‐3,4‐hexanedione dioxime (DEHD) were synthesized and their boron containing 99 Tc/ 99m Tc complexes, formed by reduction of pertechnetate with BH 4 ‐ , were isolated, purified and characterized by IR/UV/VIS spectroscopy and FAB mass spectrometry. These rather stable cationic complexes differ significantly in lipophilicity as assessed by their octanol/saline partition coefficients and HPLC capacity factors. Unexpectedly the organ uptake and clearance of both complexes in mice proved to be very similar with only the uptake of 99m Tc‐DMHD in the kidneys being enhanced.