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Synthesis Of N,N‐dimethyl‐[β‐(3,4‐diacetoxy‐6‐ 123 I‐iodophenyl)]‐ethylamine (IDDE): A potential radiotracer for the study of the dopaminergic system
Author(s) -
Adam Michael J.,
Ponce Yolanda Zea,
Berry Joffre M.,
Lu Jianming
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580310103
Subject(s) - chemistry , ethylamine , yield (engineering) , chloramine t , radiochemistry , bicyclic molecule , medicinal chemistry , organic chemistry , materials science , metallurgy
N.N‐Dimethyl‐[β‐(3,4‐Diacetoxy‐6‐ 123 I‐Iodophenyl)]ethylamine (IDDE) was synthesized by the iododemercuration reaction with [ 123 I]‐NaI and Chloramine‐T. The iodinated compound was deprotected with BBr 3 , acetylated and purified by HPLC to give the final product in 43% radiochemical yield. The radiochemical purity was >97%.