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Synthesis of radiolabelled clenbuterol analogues
Author(s) -
Pegg Graham G.,
Sillence Martin N.,
Sleeman Madonna J.,
Lindsay Derek B.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580291211
Subject(s) - clenbuterol , chemistry , sodium borohydride , ethanol , pyridinium , stereochemistry , organic chemistry , chromatography , catalysis
Oxidation of clenbuterol 1a with pyridinium chlorochromate yielded 4‐amino‐3,5‐dichloro‐α‐ tert ‐butylaminoacetophenone 5 . Tritiated clenbuterol 1b was produced by reduction of 5 with sodium [ 3 H]borohydride. Radioiodination of the clenbuterol precursor [2‐ tert ‐butylamino‐1‐(4‐aminophenyl)‐ethanol] 2 yielded [2‐ tert. ‐butylamino‐1‐(4‐amino‐3‐[ 125 I] iodophenyl)‐ethanol] 3b .