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Syntheses of 3 H‐ and 2 H‐labeled (17 R )‐17,20‐dimethyl‐7‐thiaprostaglandin E 1 methyl ester
Author(s) -
Tanaka Toshio,
Bannai Kiyoshi,
Manabe Kenji,
Kurozumi Seizi
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290810
Subject(s) - chemistry , tritium , deuterium , tetrahydrofuran , tritium illumination , medicinal chemistry , radiochemistry , organic chemistry , physics , quantum mechanics , solvent , nuclear physics
The syntheses of [19,20‐ 3 H 2 ]‐ and [3,3,4,4,5,5,6,6‐ 2 H 8 ]‐(17 R )‐ 17,20‐dimethyl‐7‐thiaprostaglandin E 1 methyl esters ( 3 and 5 ) are described. The di‐tritiated compound 3 was prepared from its protected ( Z )‐Δ 19 ‐precursor ( 21 ) via catalytic reduction with tritium gas having a specific activity of 49 Ci / mmol. The octa‐deuterated compound 5 was prepared from tetrahydrofuran‐ d 8 .