Premium
Determination of the stereochemistry of tritium label in sulbactam obtained by isotope exchange of penicillanic acid (R)‐sulphoxide benzyl ester
Author(s) -
Gibson Colin L.,
Jones John R.,
Sharratt Andrew P.,
Liss Robert H.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290803
Subject(s) - chemistry , stereospecificity , sulbactam , tritium , stereochemistry , bicyclic molecule , organic chemistry , catalysis , biochemistry , physics , antibiotics , antibiotic resistance , imipenem , nuclear physics
Sulbactam, a β‐lactamase inhibitor, has been prepared in tritiated (170 mCi mmol −1 ) form by the highly stereospecific isotope exchange procedure involving penicillanic acid (R)‐sulphoxide benzyl ester. The stereochemistry of the tritiation has been established by 3 H n.m.r. in conjunction with a 1 H NOESY spectrum of sulbactam.