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Preparation of 4,4′‐diaminodiphenylmethane‐( 2 H 4 ) for use as internal standard in the quantification of 4,4′‐diaminodiphenylmethane
Author(s) -
Natangelo Marco,
Bagnati Renzo,
Fanelli Roberto,
Gavinelli Marco,
Ulbricht Claudia,
Benfenati Emilio
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290614
Subject(s) - chemistry , mass spectrometry , deuterium , diamine , hydrochloric acid , methanol , gas chromatography , nuclear magnetic resonance spectroscopy , analytical chemistry (journal) , chromatography , organic chemistry , nuclear physics , physics
A simple method has been developed for the synthesis of 4,4′‐diaminodiphenylmethane‐( 2 H 4 ) for analytical purposes in gas chromatography‐negative ion chemical ionization mass spectrometry (GC‐NICIMS). It consists in a proton‐deuterium exchange reaction of the diamine using deutero‐hydrochloric acid in deuterated methanol. The reaction was conducted at 60°C. Deuteration of the diamine in the ortho positions of the aromatic rings was observed after eight days in these conditions, using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.