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Synthesis of (Z)‐3‐[4‐(acetyloxy)‐5‐ethyl‐3‐methoxy‐1‐NAPH‐thalenyl]‐2‐methyl‐2‐ propenoic‐2‐ 14 C acid ( 14 C‐E5090)
Author(s) -
Tanaka Masayuki,
Sakurai Hideki,
Yoshimura Tsutomu
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290613
Subject(s) - chemistry , yield (engineering) , ethyl ester , stereochemistry , medicinal chemistry , organic chemistry , metallurgy , materials science
(Z)‐3‐[4‐(Acetyloxy)‐5‐ethyl‐3‐methoxy‐1‐naphthalenyl]‐2‐methyl‐2‐propenoic‐2‐ 14 C acid 7 ( 14 C‐E5090) was synthesized in order to study the pharmacokinetic profile of E5090, an orally active inhibitor of IL‐1 generation. 14 C‐E5090 with a specific activity of 43.34mCi/mmol was prepared in 5 steps in 12.9% overall yield from 5‐ethyl‐3‐methoxy‐4‐methoxymethoxy‐1‐naphthalenecarbaldehyde 1 .