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An efficient synthesis of 2‐ [ carbonyl ‐ 11 C]acetamido‐2‐deoxy‐D‐glucopyranose ( N ‐[ carbonyl ‐ 11 C]acetyl‐D‐glucosamine)
Author(s) -
Tada Masao,
Oikawa Atsushi,
Iwata Ren,
Sato Kazunori,
Sugiyama Hiroshi,
Kubota Kazuo,
Ishiwata Kiichi,
Takahashi Hiromu,
Wakui Akira,
Abe Yoshinao,
Yamaguchi Tatsuo,
Fujiwara Takehiko,
Sato Tachio,
Ido Tatsuo
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290414
Subject(s) - chemistry , d glucopyranose , yield (engineering) , acetic acid , glucosamine , carbon 14 , chemical synthesis , d glucosamine , carbon dioxide , medicinal chemistry , stereochemistry , organic chemistry , nuclear chemistry , biochemistry , materials science , physics , quantum mechanics , metallurgy , in vitro
A rapid chemical synthesis of 2‐[ carbonyl‐ 11 C ]acetamido‐2‐deoxy‐D‐glucopyranose ( N ‐[ carbonyl ‐ 11 C]acetyl‐D‐glucosamine) starting from [ 11 C]carbon dioxide is described. The total time required for the synthesis, the radiochemical yield, and purity of the titled sugar are ca. 60 min, 49.5% (based on [ carbonyl ‐ 11 C]acetic acid), and >98%, respectively.