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Preparation of 4‐phenylbutyric [2,3‐ 2 H 2 ]‐, [4,4‐ 2 H 2 ]‐, [2,3,4,4‐ 2 H 4 ]‐, and [2,2,3,3,4,4‐ 2 H 6 ]‐acids by use of crossed kolbe electrolysis as a key reaction
Author(s) -
Tashiro Masashi,
Tsuzuki Hirohisa,
Goto Hideyuki,
Ogasahara Shoji,
Mataka Shuntaro
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290413
Subject(s) - chemistry , hydrogen , stereochemistry , medicinal chemistry , tritium , organic chemistry , physics , nuclear physics
The four deuteriated 4‐phenylbutyric [2,3‐ 2 H 2 ]‐, [4,4‐ 2 H 2 ]‐, [2,3,4,4‐ 2 H 4 ]‐, and [2,2,3,3,4,4‐ 2 H 6 ]‐acids have been synthesized in high isotopic purity by utilizing crossed Kolbe electrolysis of methyl hydrogen [ 2 H 0 ]‐, [2,3‐ 2 H 2 ], and [2,3,3,3‐ 2 H 4 ]‐succinates and phenyl acetic [ 2 H 0 ] and [ 2 H 2 ]‐acids as a key reaction.