Premium
Synthesis and evaluation of [ 3 H]‐4‐fluoro‐1‐[1‐(3‐hydroxyphenyl)cyclohexyl]piperidine, a potential tool for autoradiographic study of the phencyclidine receptor
Author(s) -
de Costa Brian R.,
Mattson Mariena V.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290109
Subject(s) - phencyclidine , piperidine , chemistry , receptor , sigma receptor , ligand (biochemistry) , stereochemistry , tritium , in vitro , pharmacology , biochemistry , nmda receptor , medicine , physics , nuclear physics
The synthesis and in vitro binding of high specific activity tritium labelled 4‐fluoro‐1‐[1‐(3‐hydroxyphenyl)cyclohexyl] piperidine ([ 3 H]FOH‐PCP), a potential probe for autoradiographic study of the phencyclidine (PCP) receptor is described. [ 3 H]FOH‐PCP will allow evaluation of [ 18 F]FOH‐PCP as a PET scanning ligand for PCP receptors.